A heavyweight Premier League match-up as Chelsea host champions Manchester City at Stamford Bridge.
Brentford welcome Liverpool to Brentford Community Stadium in a game from the Premier League.
Southampton welcome Wolverhampton Wanderers to St Mary's Stadium in a game from the Premier League.
Arsenal welcome Tottenham Hotspur to Emirates Stadium for the highly-anticipated North London Derby.
Crystal Palace welcome rivals Brighton and Hove Albion to Selhurst Park in the Premier League. The high-flying Seagulls come here with four wins from their opening five.
Action from the Champions League as PSG's star-studded team welcome Manchester City's superstars to Parc des Princes. Man City opened their campaign with a 6-3 win over RB Leipzig.
Action from Group B of the Champions League as Porto and Liverpool face-off at Estadio do Dragao. Liverpool are unbeaten in eight against their Portuguese opponents, winning five.
Action from Group H of the UEFA Champions League as Juventus and Chelsea face-off at Allianz Stadium. Chelsea are unbeaten in their last 12 group stage fixtures in this competition.
Action from the Champions League as Manchester United host Villarreal at Old Trafford. Villarreal claimed the trophy when the two met in last season's Europa League final.
Action from Group C in the UEFA Europa League as Legia Warsaw and Leicester face-off at Polish Army Stadium.
Action from the UEFA Europa League as Steven Gerrard's Rangers side travel to Czech Republic to face Sparta Prague.
Action from the UEFA Europa Conference League as Tottenham and NS Mura face-off at the Tottenham Hotspur Stadium.
UEFA Europa League action as Celtic host German side Bayer Leverkusen at Celtic Park.
Action from the UEFA Europa League as West Ham host Austrian side Rapid Vienna at London Stadium.