Jurgen Klopp's Liverpool side welcome Ajax to Anfield in the UEFA Champions League. Liverpool are on a 14-game unbeaten run against Dutch opposition.
Manchester City travel to face Porto in the UEFA Champions League at the Estadio do Dragao. City have won each of their last three meetings with Porto.
Manchester United welcome PSG to Old Trafford for their UEFA Champions League clash. The away side has won all three of the previous European meetings between United and PSG.
Chelsea face Sevilla in the UEFA Champions League at Ramon Sanchez-Pizjuan Stadium. Chelsea have only won one of their last 10 UCL games against Spanish opponents.
Zorya Luhansk and Leicester City meet in the UEFA Europa League at Slavutych-Arena. Leicester won the reverse fixture on matchday one 3-0.
Action from the UEFA Europa League as Austrian side LASK host Jose Mourinho's Tottenham. Spurs are unbeaten in all five of their previous meetings with Austrian opponents.
AC Milan and Celtic go toe-to-toe in the UEFA Europa League at the San Siro. Milan have lost just one of their 11 previous meetings with Celtic in all competitions.
Mikel Arteta's Arsenal host Rapid Vienna in the UEFA Europa League at the Emirates Stadium. Joe Willock has been directly involved in five goals in his last three UEL games.
Steven Gerrard's Rangers welcome Belgian side Standard Liege to Ibrox Stadium in the UEFA Europa League. A Rangers win will guarantee their progression to the knockout stage.
Dean Smith's Aston Villa welcome Steve Bruce's Newcastle United to Villa Park in Friday Night Football action from the Premier League.